研究実績Achievement

2020

Matsuzaki Y, Shimotai Y, Kadowaki Y, Sugawara K, Hongo S, Mizuta K, Nishimura H. Antigenic changes among the predominantly circulating C/Sao Paulo lineage strains of influenza C virus in Yamagata, Japan, between 2015 and 2018. Infect Genet Evol. 2020 Jul;81:104269.

Liao F, Nishimura H, Ito H, Zhang Y, Matsuzaki Y. Longitudinal course of influenza C virus antibody titers of healthy adults in Sendai, Japan. J Clin Virol. 2020 Dec;133:104662.

Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y: Regional spread of three distinct genotypes of Mycoplasma pneumoniae and different timing of macrolide-resistant strain appearance among genotypes between 2011 and 2013 in Yamagata, Japan. Yamagata Med J. 2020 Feb; 38(1): 19-24

Komabayashi K, Seto J, Matoba Y, Aoki Y, Tanaka S, Ikeda T, Matsuzaki Y, Itagaki T, Mizuta K. Seasonality of Human Coronavirus OC43, NL63, HKU1, and 229E Infection in Yamagata, Japan, 2010-2019. Jpn J Infect Dis. 2020 Sep 24;73(5):394-397. doi: 10.7883/yoken.JJID.2020.525.

Yamaya M, Nishimura H, Deng X, Sugawara M, Watanabe O, Nomura K, Shimotai Y, Momma H, Ichinose M, Kawase T. Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells. Respir Investig. 2020 May;58(3):155-168. doi: 10.1016/j.resinv.2019.12.005.

2019

Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y: Polyclonal spread of multiple genotypes of Mycoplasma pneumoniae in semi-closed settings in Yamagata, Japan. J Med Microbiol. 2019 May; 68(5): 785-790

Yamaya M, Nishimura H, Lusamba Kalonji N, Deng X, Momma H, Shimotai Y, Nagatomi R. Effects of high temperature on pandemic and seasonal human influenza viral replication and infection-induced damage in primary human tracheal epithelial cell cultures. Heliyon. 2019; 5(2): e01149

Mizuta K, Tanaka S, Komabayashi K, Aoki Y, Itagaki T, Katsushima F, Katsushima Y, Yoshida H, Ito S, Matsuzaki Y, Ikeda T. Phylogenetic and antigenic analyses of coxsackievirus A6 isolates in Yamagata, Japan between 2001 and 2017. Vaccine. 2019; 37(8): 1109-1117

2018

Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Mizuta K, Nishimura H. Neutralizing epitopes and residues mediating the potential antigenic drift of the hemagglutinin-esterase protein of influenza C virus. Viruses. 2018; 10(8): 417

Itagaki T, Aoki Y, Matoba Y, Tanaka S, Ikeda T, Mizuta K, Matsuzaki Y. Clinical characteristics of children infected with enterovirus D68 in an outpatient clinic and the association with bronchial asthma. Infect Dis (Lond). 2018; 50(4): 303-312

Matoba Y, Aoki Y, Tanaka S, Unno M, Komabayashi K, Ikeda T, Shimotai Y, Matsuzaki Y, Itagaki T, Mizuta K. Trends of human coronaviruses in Yamagata, Japan in 2015-2016 focusing on the OC43 outbreak of June 2016. Jpn J Infect Dis. 2018; 71(2): 167-169

Takahashi M, Obara T, Matsuzaki Y, Maisawa SI, Sasaki Y, Yoshino N, Shirasawa A, Iwabuchi K, Takahashi T, Kajita H, Ono Y, Ryo A, Kimura H, Muraki Y. Cocirculation of influenza C viruses with distinct internal genome constellations in Iwate prefecture, Japan, in 2016. Jpn J Infect Dis. 2018; 71(5): 393-395

Trost JF, LeMasters EH, Liu F, Carney P, Lu X, Sugawara K, Hongo S, Stevens J, Steinhauer DA, Tumpey T, Katz JM, Levine MZ, Li ZN. Development of a high-throughput assay to detect antibody inhibition of low pH induced conformational changes of influenza virus hemagglutinin. PLoS One. 2018; 13(6): e0199683

Fujii K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Mizuta K, Matsuzaki Y, Koike S. VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection. J Virol. 2018; 92(15): e00682-18

Itagaki T, Aoki Y, Matoba Y, Tanaka S, Ikeda T, Matsuzaki Y, Mizuta K. Detection of Saffold viruses from children with acute respiratory infections in Yamagata, Japan, between 2008 and 2015. J Med Virol. 2018; 90(1): 34-40

勝島由利子,勝島史夫,水田克巳,松嵜葉子:パラインフルエンザウイルスが分離された発疹症の4例.小児科診療 2018; 81(1): 125-128

2017

Goto T, Shimotai Y, Matsuzaki Y, Muraki Y, Sho R, Sugawara K, Hongo S. Effect of Phosphorylation of CM2 Protein on Influenza C Virus Replication. J Virol. 2017; 91(22): e00773-17

Okuwa T, Sasaki Y, Matsuzaki Y, Himeda T, Yoshino N, Hongo S, Ohara Y, Muraki Y. The epitope sequence of S16, a monoclonal antibody against influenza C virus hemagglutinin-esterase fusion glycoprotein. Future Virol. 2017; 12(3): 93-101

Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y. Multiple-Locus Variable-Number Tandem-Repeat Analysis of Mycoplasma pneumoniae Isolates between 2004 and 2014 in Yamagata, Japan: Change in Molecular Characteristics during an 11-year Period. Jpn J Infect Dis. 2017; 70(6): 642-646

Suzuki Y, Shimotai Y, Itagaki T, Seto J, Ikeda T, Yahagi K, Mizuta K, Hongo S, Matsuzaki Y. Development of macrolide resistance-associated mutations after macrolide treatment in children infected with Mycoplasma pneumoniae. J Med Microbiol. 2017; 66(11): 1531-1538

板垣勉,的場洋平,水田克巳,松嵜葉子:2015年山形市近郊で流行したコロナウイルスOC43感染症.日本小児科医会会報 2017; 53: 131-134

2016

Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Oshitani H, Mizuta K, Nishimura H: Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014. J Virol. 2016;90(18):8251-8265

Furuse Y, Matsuzaki Y, Nishimura H, Oshitani H: Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses. Viruses. 2016;8(12):E321.

Suzuki Y, Seto J, Shimotai Y, Ikeda T, Yahagi K, Mizuta K, Matsuzaki Y, Hongo S: Development of an endpoint genotyping assay to detect the Mycoplasma pneumoniae 23S rRNA gene and distinguish the existence of macrolide resistance-associated mutations at position 2063. J Microbiol Methods. 2016;131:130-134

Tanaka S, Aoki Y, Matoba Y, Yahagi K, Itagaki T, Matsuzaki Y, Mizuta K: Seroepidemiology of human parechovirus types 1, 3, and 6 in Yamagata, Japan, in 2014. Microbiol Immunol. 2016;60(12):854-858

Matoba Y, Aoki Y, Tanaka S, Yahagi K, Katsushima Y, Katsushima F, Sugawara K, Matsuzaki Y, Mizuta K: HeLa-ACE2-TMPRSS2 Cells Are Useful for the Isolation of Human Coronavirus 229E. Jpn J Infect Dis. 2016;69(5):452-454

2015

Shimotai Y, Goto T, Matsuzaki Y, Muraki Y, Sugawara K, Hongo S: The effect of thecytoplasmic tail of influenza C virus CM2 protein on its biochemical properties and intracellular processing. Biochemistry and Biophysics Reports 2015;3:1-6

Shimizu Y, Abiko C, Ikeda T, Mizuta K, Matsuzaki Y: Influenza C virus and human metapneumovirus infections in hospitalized children with lower respiratory tract illness. Pediatr Infect Dis J. 2015; 34(11):1273-1275

Matoba Y, Aoki Y, Tanaka S, Yahagi K, Shimotai Y, Matsuzaki Y, Itagaki T, Mizuta K: An outbreak of human coronavirus OC43 during the 2014-2015 influenza season in Yamagata, Japan. Jpn J Infect Dis. 2015;68(5):442-445

Aoki Y, Matoba Y, Tanaka S, Yahagi K, Hirokawa C, Tamura T, Itagaki T, Matsuzaki Y, Mizuta K: Isolation of saffold virus type 2 from children with acute respiratory infections by using the RD-18S-Niigata cell line. Jpn J Infect Dis. 2015;68(5):438-441

Furukawa T, Shimotai Y, Ohta N, Ishida A, Kurakami K, Suzuki H, Yamakawa M, Hongo S, Kakehata S: Epstein-Barr virus in the enlarged salivary tissues of patients with IgG4-related disease. Laryngoscope 2015;125(9):2079-2084

Yamaya M, Shimotai Y, Hatachi Y, Lusamba Kalonji N, Tando Y, Kitajima Y, Matsuo K, Kubo H, Nagatomi R, Hongo S, Homma M, Nishimura H: The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells. Pulm Pharmacol Ther. 2015;33:66-74

Odagiri T, Matsuzaki Y, Okamoto M, Suzuki A, Saito M, Tamaki R, Lupisan SP, Sombrero LT, Hongo S, Oshitani H: Isolation and characterization of influenza C viruses in the Philippines and Japan. J Clin Microbiol. 2015;53(3):847-858

Tanaka S, Aoki Y, Matoba Y, Yahagi K, Mizuta K, Itagaki T, Katsushima F, Katsushima Y, Matsuzaki Y: The dominant antigenic group of influenza C infections changed from C/Sao paulo/378/82-lineage to C/Kanagawa/1/76-lineage in Yamagata, Japan, in 2014. Jpn J Infect Dis. 2015;68(2):166-168

Matoba Y, Abiko C, Ikeda T, Aoki Y, Suzuki Y, Yahagi K, Matsuzaki Y, Itagaki T, Katsushima F, Katsushima Y, Mizuta K: Detection of the human coronavirus 229E, HKU1, NL63 and OC43 between 2010 and 2013 in Yamagata, Japan. Jpn J Infect Dis. 2015;68(2):138-141

Matoba Y, Aoki Y, Tanaka S, Yahagi K, Itagaki T, Matsuzaki Y, Mizuta K: Picornavirus-like cytopathic effects on RD-18S cell lines were induced by human coronavirus 229E not picornaviruses. Jpn J Infect Dis. 2015;68(1):78-79

Katsushima Y, Katsushima F, Suzuki Y, Seto J, Mizuta K, Nishimura H, Matsuzaki Y: Characteristics of Mycoplasma pneumoniae infection identified on culture in a pediatric clinic. Pediatr Int. 2015; 57(2):247-252

鈴木裕,瀬戸順次,板垣勉,青木敏也,安孫子千恵子,松嵜葉子:山形県で2004年から2013年の10年間に分離したMycoplasma pneumoniaeのマクロライド耐性遺伝子変異およびp1遺伝子型解析.感染症学雑誌 2015;89(1):16-22

2014

Matsuzaki Y, Sugawara K, Nakauchi M, Takahashi Y, Onodera T, Tsunetsugu-Yokota Y, Matsumura T, Ato M, Kobayashi K, Shimotai Y, Mizuta K, Hongo S, Tashiro M, Nobusawa E: Epitope mapping of the hemagglutinin molecule of A/(H1N1)pdm09 influenza virus by using monoclonal antibody escape mutants. J Virol. 2014;88(21):12364-12373

Matsuzaki Y, Sugawara K, Abiko C, Ikeda T, Aoki Y, Mizuta K, Katsushima N, Katsushima F, Katsushima Y, Itagaki T, Shimotai Y, Hongo S, Muraki Y, Nishimura H: Epidemiological information regarding the periodic epidemics of influenza C virus in Japan (1996-2013) and the seroprevalence of antibodies to different antigenic groups. J Clin Virol. 2014;61(1):87-93

Mizuta K, Aoki Y, Matoba Y, Yahagi K, Itagaki T, Katsushima F, Katsushima Y, Ito S, Hongo S, Matsuzaki Y: Molecular epidemiology of enterovirus 71 strains isolated from children in Yamagata, Japan, between 1990 and 2013. J Med Microbiol. 2014;63(10):1356-1362

Yano T, Maeda C, Akachi S, Matsuno Y, Yamadera M, Kobayashi T, Nagai Y, Iwade Y, Kusuhara H, Katayama M, Fukuta M, Nakagawa Y, Naraya S, Takahashi H, Hiraoka M, Yamauchi A, Nishinaka T, Amano H, Yamaguchi T, Ochiai H, Ihara T, Matsuzaki Y: Phylogenetic analysis and seroprevalence of influenza C virus in Mie prefecture, Japan in 2012. Jpn J Infect Dis. 2014;67(2):127-131

Imamura T, Okamoto M, Nakakita S, Suzuki A, Saito M, Tamaki R, Lupisan S, Roy CN, Hiramatsu H, Sugawara KE, Mizuta K, Matsuzaki Y, Suzuki Y, Oshitani H: Antigenic and receptor binding properties of enterovirus 68. J Virol. 2014;88(5):2374-2384

Tajima K, Nishimura H, Hongo S, Hazawa M, Saotome-Nakamura AI, Tomiyama K, Obara C, Kato T: Estimation of secondary measles transmission from a healthcare worker in a hospital setting. Int J Infect Dis. 2014;24:11-13

2013

Matsuzaki Y, Itagaki T, Ikeda T, Aoki Y, Abiko C, Mizuta K. Human metapneumovirus infection among family members. Epidemiol Infect. 2013;141(4):827-832

Suzuki Y, Itagaki T, Seto J, Kaneko A, Abiko C, Mizuta K, Matsuzaki Y. Community Outbreak of Macrolide-resistant Mycoplasma pneumoniae in Yamagata, Japan in 2009. Pediatr Infect Dis J. 2013;32(3):237-240

Itagaki T, Suzuki Y, Seto J, Abiko C, Mizuta K, Matsuzaki Y. Two cases of macrolide resistance in Mycoplasma pneumoniae acquired during the treatment period. J Antimicrob Chemother. 2013;68(3):724-725

Mizuta K, Abiko C, Aoki Y, Ikeda T, Matsuzaki Y, Itagaki T, Katsushima F, Katsushima Y, Noda M, Kimura H, Ahiko T. Seasonal patterns of respiratory syncytial virus, influenza A virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan. Jpn J Infect Dis. 2013;66(2):140-145

Mizuta K, Abiko C, Aoki Y, Ikeda T, Matsuzaki Y, Hongo S, Itagaki T, Katsushima N, Ohmi A, Nishimura H, Ahiko T. Molecular epidemiology of Coxsackievirus A16 strains isolated from children in Yamagata, Japan between 1988 and 2011. Microbiol Immunol. 2013,57(5):400-405

Muraki Y, Okuwa T, Himeda T, Hongo S, Ohara Y. Effect of cysteine mutations in the extracellular domain of CM2 on the influenza C virus replication. PLoS One. 2013;8(4):e60510

2012

Matsuzaki Y, Ikeda T, Abiko C, Aoki Y, Mizuta K, Shimotai Y, Sugawara K, Hongo S: Detection and quantification of influenza C virus in pediatric respiratory specimens by real-time PCR and comparison with infectious viral counts. J Clin Virol 2012;54(2):130-134

Takashita E, Muraki Y, Sugawara K, Asao H, Nishimura H, Suzuki K, Tsuji T, Hongo S, Ohara Y, Kawaoka Y, Ozawa M, Matsuzaki Y. Intrinsic temperature sensitivity of influenza C virus hemagglutinin-esterase-fusion protein. J Virol 2012;86(23):13108-13111

Mizuta K, Abiko C, Aoki Y, Ikeda T, Itagaki T, Katsushima F, Katsushima Y, Matsuzaki Y, Noda M, Kimura H, Ahiko T. Epidemiology of parainfluenza virus types 1, 2 and 3 infections based on virus isolation between 2002 and 2011 in Yamagata, Japan. Microbiol Immunol 2012;56(12):855-858

Ikeda T, Mizuta K, Abiko C, Aoki Y, Itagaki T, Katsushima F, Katsushima Y, Matsuzaki Y, Fuji N, Imamura T, Oshitani H, Noda M, Kimura H, Ahiko T: Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010. Microbiol Immunol 2012;56(2):139-143

Muraki Y, Hongo S, Ohara Y: Contamination of the cell sorter fluidics system with the water-borne bacterium Burkholderia cepacia. Cytometry A 2012;81(2):105-107

清水行敏,松嵜葉子,秋葉香,荻野大助,前田勝子,笹真一,水田克巳,早坂清:入院患者を対象とした小児呼吸器感染症におけるヒトメタニューモウイルス迅速診断キットの有用性.小児科臨床2012;65(12): 2643-2647

2011

Furukawa T, Muraki Y, Noda T, Takashita E, Sugawara K, Matsuzaki Y, Shimotai Y, Hongo S: Role of the CM2 protein in the influenza C virus replication cycle. J Virol 2011;85(3):1322-1329

Muraki Y, Okuwa T, Furukawa T, Matsuzaki Y, Sugawara K, Himeda T, Hongo S, Ohara Y: Palmitoylation of CM2 is dispensable to influenza C virus replication. Virus Res 2011;157(1):99-105

Itagaki T, Abiko C, Aoki Y, Ikeda T, Mizuta K, Noda M, Kimura H, Matsuzaki Y: Saffold cardiovirus infection in children associated with respiratory disease and its similarity to coxsackievirus infection. Pediatr Infect Dis J 2011;30(8):680-683

板垣勉,松嵜葉子: ヒトメタニューモウイルス感染症の臨床経過とウイルス排出期間の検討. 日本小児科学会雑誌 2011;115(4):782-787

2010

Matsuzaki Y, Mizuta K, Aoki Y, Suto A, Abiko C, Sanjoh K, Sugawara K, Takashita E, Itagaki T, Katsushima Y, Ujike M, Obuchi M, Odagiri T, Tashiro M: A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir. Virol J 2010;7(1):53

Matsuzaki Y, Mizuta K, Takashita E, Okamoto M, Itagaki T, Katsushima F, Katsushima Y, Nagai Y, Nishimura H: Comparison of virus isolation using the Vero E6 cell line with real-time RT-PCR assay for the detection of human metapneumovirus. BMC Infect Dis 2010;10:170

Muraki Y, Furukawa T, Kohno Y, Matsuzaki Y, Takashita E, Sugawara K, Hongo S: Influenza C virus NS1 protein upregulates the splicing of viral mRNAs. J Virol 2010;84(4):1957-1966

Okamoto M, Sugawara K, Takashita E, Muraki Y, Hongo S, Nishimura H, Matsuzaki Y: Longitudinal course of human metapneumovirus antibody titers and reinfection in healthy adults. J Med Virol 2010;82(12):2092-2096

Okamoto M, Sugawara K, Takashita E, Muraki Y, Hongo S, Mizuta K, Itagaki T, Nishimura H, Matsuzaki Y: Development and evaluation of a whole virus-based enzyme-linked immunosorbent assay for the detection of human metapneumovirus antibodies in human sera. J Virol Methods 2010;164(1-2):24-29

Mizuta K, Abiko C, Aoki Y, Ikeda T, Itagaki T, Katsushima N, Matsuzaki Y, Hongo S, Noda M, Kimura H, Ahiko T: Endemicity of human metapneumovirus subgenogroups A2 and B2 in Yamagata, Japan, between 2004 and 2009. Microbiol Immunol 2010;54(10):634-638

Aoki Y, Suto A, Mizuta K, Ahiko T, Osaka K, Matsuzaki Y: Duration of norovirus excretion and the longitudinal course of viral load in norovirus-infected elderly patients. J Hosp Infect 2010;75(1):42-46

Yasuda T, Yamaki M, Iimura A, Shimotai Y, Shimizu K, Noshita T, Funayama S: Anti-influenza virus principles from Muehlenbeckia hastulata. J Nat Med 2010;64(2):206-211.

2009

Kohno Y, Muraki Y, Matsuzaki Y, Takashita E, Sugawara K, Hongo S : Intracellular localization of influenza C virus NS2 protein (NEP) in infected cells and its incorporation into virions. Arch Virol. 154: 235-243, 2009.

Muraki Y, Hay A : Establishment of mouse erythroleukemia cell line expressing influenza C virus CM2 protein and a chimeric protein between CM2 and influenza A virus M2 protein. Acta Virol. 53, 2009 (accepted).

2008

Mizuta K, Abiko C, Aoki Y, Suto A, Hoshina H, Itagaki T, Katsushima N, Matsuzaki Y, Hongo S, Noda M, Kimura H, Ootani K: Analysis of monthly isolation of respiratory viruses from children by cell culture using a microplate method: a two-year study from 2004 to 2005 in Yamagata, Japan. Jpn J Infect Dis. 61:196-201, 2008.

2007

Muraki Y, Murata T, Takashita E, Matsuzaki Y, Sugawara K, Hongo S. : A mutation on influenza C virus M1 protein affects virion morphology by altering the membrane affinity of the protein. J Virol. 81: 8766-8773, 2007.

Abiko C, Mizuta K, Itagaki T, Katsushima N, Ito S, Matsuzaki Y, Okamoto M, Nishimura H, Aoki Y, Murata T, Hoshina H, Hongo S, Ootani K. : Outbreak of human metapneumovirus detected by use of the Vero E6 cell line in isolates collected in Yamagata, Japan, in 2004 and 2005. J Clin Microbiol. 45: 1912-1919, 2007.

Matsuzaki Y, Abiko C, Mizuta K, Sugawara K, Takashita E, Muraki Y, Suzuki H, Mikawa M, Shimada S, Sato K, Kuzuya M, Takao S, Wakatsuki K, Itagaki T, Hongo S, Nishimura H. : A nationwide epidemic of influenza C virus infection in Japan in 2004.  J Clin Microbiol. 45: 783-788, 2007.

Kawaguchi K, Inamura H, Abe Y, Koshu H, Takashita E, Muraki Y, Matsuzaki Y, Nishimura H, Ishikawa H, Fukao A, Hongo S, Aoyagi M. : Reactivation of herpes simplex virus type 1 and varicella-zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy. Laryngoscope. 117: 147-156, 2007.

Murata T, Katsushima N, Mizuta K, Muraki Y, Hongo S, Matsuzaki Y. : Prolonged norovirus shedding in infants

2006

Arawaka, S., Wada, M., Goto, S., Karube, H., Sakamoto, M., Ren, CH., Koyama, S., Nagasawa, H., Kimura, H., Kawanami, T., Kurita, K., Tajima, K., Daimon, M., Baba, M., Kido, T., Saino, S., Goto, K., Asao, H., Kitanaka, C., Takashita, E., Hongo, S., Nakamura, T., Kayama, T., Suzuki, Y., Kobayashi, K., Katagiri, T., Kurokawa, K., Kurimura, M., Toyoshima, I., Niizato, K., Tsuchiya, K., Iwatsubo, T., Muramatsu, M., Matsumine, H., Kato, T. : The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.  J Neurosci. 26: 9227-9238, 2006.

Sugawara, K., Muraki, Y., Takashita, E., Matsuzaki, Y., Hongo, S. : Conformational maturation of the nucleoprotein synthesized in influenza C virus-infected cells. Virus Res. 122: 45-52, 2006.

Matsuzaki, Y., Katsushima, N., Nagai, Y., Shoji, M., Itagaki,T., Sakamoto, M., Kitaoka, S., Mizuta, K., Nishimura, H. : Clinical features of influenza C virus infection in children.  J Infect Dis. 193: 1229-1235, 2006.

2005

Mizuta, K., Abiko, C., Murata, T., Matsuzaki, Y., Itagaki, T., Sanjoh, K., Sakamoto, M., Hongo, S., Murayama, S., Hayasaka, K. : Frequent importation of enterovirus 71 from surrounding countries into the local community of Yamagata, Japan, between 1998 and 2003.  J Clin Microbiol. 43: 6171-6175, 2005.

Mizuta, K., Abiko, C., Murata, T., Yamada, K., Ahiko, T., Sakamoto, M., Tsuchida, S., Matsuzaki, Y., Hongo, S., Sunagawa, T., Kudo, K. : An outbreak of measles virus infection due to a genotype D9 at a junior high school in Yamagata, Japan in 2004.  Jpn J Infect Dis. 58: 98-100, 2005.

Matsuzaki, Y., Sato, K., Sugawara, K., Takashita, E., Muraki, Y., Morishita, T., Kumagai, N., Suzuki, S., Hongo, S. : Isolation of an influenza C virus introduced into Japan by a traveler from Malaysia. J Clin Microbiol. 43: 993-995, 2005.

2004

Abe, Y., Takashita, E., Sugawara, K., Matsuzaki, Y., Muraki, Y., Hongo, S. : Effect of the addition of oligosaccharides on the biological activities and antigenicity of influenza A/H3N2 virus hemagglutinin. J Virol. 78: 9605-9611, 2004.

Matsuzaki, Y., Takao, S., Shimada, S., Mizuta, K., Sugawara, K., Takashita, E., Muraki, Y., Hongo, S., Nishimura, H. : Characterization of antigenically and genetically similar influenza C viruses isolated in Japan during the 1999-2000 season. Epidemiol Infect. 132: 709-720, 2004.

Matsuzaki, Y., Sugawara, K., Takashita, E., Muraki, Y., Hongo, S., Katsushima, N., Mizuta, K., Nishimura, H. : Genetic diversity of influenza B virus: The frequent reassortment and cocirculation of the genetically distinct reassortant viruses in a community. J. Med. Virol. 74: 132-140, 2004.

Muraki, Y., Washioka, H., Sugawara, K., Matsuzaki, Y., Takashita, E., Hongo, S. : Identification of an amino acid residue on influenza C virus M1 protein responsible for formation of the cord-like structures of the virus. J. Gen. Virol. 85: 1885-1893, 2004.

Li, Z-N., Muraki, Y., Takashita, E., Matsuzaki, Y., Sugawara, K., Hongo, S. : Biochemical properties of the P42 protein encoded by RNA segment 6 of influenza C virus. Arch. Virol. 149: 275-287, 2004.

Hongo, S., Ishii, K., Mori, K., Takashita, E., Muraki, Y., Matsuzaki, Y., Sugawara, K. : Detection of ion channel activity in Xenopus laevis oocytes expressing influenza C virus CM2 protein. Arch. Virol. 149: 35-50, 2004.

2003

Matsuzaki, Y., Mizuta, K., Sugawara, K., Tsuchiya, E., Muraki, Y., Hongo, S., Suzuki, H., Nishimura, H. : Frequent reassortment among influenza C viruses. J. Virol. 77: 871-881, 2003.

2002

Tsuchiya, E., Sugawara, K., Hongo, S., Matsuzaki, Y., Muraki, Y., Li, Z-N., Nakamura, K. : Role of overlapping glycosylation sequons in antigenic properties, intracellular transport and biological activities of influenza A/H2N2 virus haemagglutinin. J. Gen. Virol. 83: 3067-3074, 2002.

Tsuchiya, E., Sugawara, K., Hongo, S., Matsuzaki, Y., Muraki, Y., Li, Z-N., Nakamura, K. : Effect of addition of new oligosaccharide chains to the globular head of influenza A/H2N2 virus haemagglutinin on the intracellular transport and biological activities of the molecule. J. Gen. Virol. 83: 1137-1146, 2002.

Matsuzaki, Y., Sugawara, K., Mizuta, K., Tsuchiya, E., Muraki, Y., Hongo, S., Suzuki, H., Nakamura, K. : Antigenic and genetic characterization of influenza C viruses which caused two outbreaks in Yamagata City, Japan, in 1996 and 1998. J. Clin. Microbiol. 40: 422-429, 2002.

2001

Muyanga, J., Matsuzaki, Y., Sugawara, K., Kimura, K., Mizuta, K., Ndumba, I.,Muraki, Y., Tsuchiya, E., Hongo, S., Kasolo, F. C., Numazaki. Y., Nakamura, K. : Antigenic and genetic analyses of influenza B viruses isolated in Lusaka, Zambia in 1999. Arch. Virol. 146: 1667-1679, 2001.

Tsuchiya, E., Sugawara, K., Hongo, S., Matsuzaki, Y., Muraki, Y., Li, Z-N., Nakamura, K. : Antigenic structure of the haemagglutinin of human influenza A/H2N2 virus. J. Gen. Virol. 82: 2475-2484, 2001.

Sugahara, K., Hongo, S., Sugawara, K., Li, Z-N., Tsuchiya, E., Muraki, Y., Matsuzaki, Y., Nakamura, K. : Role of individual oligosaccharide chains in antigenic properties, intracellular transport, and biological activities of influenza C virus hemagglutinin-esterase protein. Virology 285: 153-164, 2001.

Li, Z-N., Hongo, S., Sugawara, K., Sugahara, K., Tsuchiya, E., Matsuzaki, Y., Nakamura, K. : The sites for fatty acylation, phosphorylation and intermolecular disulphide bond formation of influenza C virus CM2 protein. J. Gen. Virol. 82: 1085-1093, 2001.